This one is too good to not to post. If you can get past the chemistry (or don't want to deal with the chemistry) skip to the concluding remarks for the gist of the paper. The abstract also provides a pretty good insight. If you can understand the chemistry, this paper is fascinating and offers new insights into the human metabolic system and has implication for the last 50 years of metabolic research!
Enjoy
http://www.ploscompbiol.org/article/info:doi%2F10.1371%2Fjournal.pcbi.1002116
